Cytokines in immunity and inflammation group

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Jean-Christophe RENAULD, Member
Jacques VAN SNICK, Member
Laure DUMOUTIER, Assistant Member

Magali de HEUSCH, Postdoctoral Fellow
Laurent KNOOPS, Postdoctoral Fellow
Muriel LEMAIRE, Postdoctoral Fellow
Reece MARILLIER, Postdoctoral Fellow
Perrine COCHEZ, PhD Student
Amandine SAUMET, PhD Student
Lorraine SPRINGUEL, PhD Student
Astrid VAN BELLE , PhD Student
Isabelle BAR, Technician
Pamela CHEOU, Technician
Emilie HENDRICKX, Technician
Monique STEVENS, Technician


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The cytokine group studies the biology of Interleukin-9 (IL-9) and IL-22, two cytokines discovered at the Branch. IL-9 is a TH2 cytokine that plays a role in immune responses against intestinal parasites and asthma. IL-22, originally identified as a gene induced by IL-9 in T lymphocytes, upregulates the production of acute phase reagents in the liver. Its activity in inflammatory responses is modulated by a specific antagonist, the IL-22 binding protein (IL-22BP). The role of IL-9 and IL-22 in inflammation is currently being investigated using transgenic and gene-targeted mice for these cytokines and their receptors.

Selected publications

  1. Renauld JC, van der Lugt N, Vink A, van Roon M, Godfraind C, Warnier G, Merz H, Feller A, Berns A, Van Snick J. Thymic lymphomas in interleukin 9 transgenic mice. Oncogene 1994; 9:1327-32.
  2. Vink A, Warnier G, Brombacher F, Renauld JC. Interleukin 9-induced in vivo expansion of the B-1 lymphocyte population. J Exp Med 1999;189:1413-23.
  3. Richard M, Grencis RK, Humphreys NE, Renauld JC, Van Snick J. Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice. Proc Natl Acad Sci U S A 2000;97:767-72.
  4. Steenwinckel V, Louahed J, Orabona C, Huaux F, Warnier G, McKenzie A, Lison D, Levitt R, Renauld JC. IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells. J Immunol. 2007; 178:3244-51.
  5. Renauld JC, Druez C, Kermouni A, Houssiau F, Uyttenhove C, Van Roost E, Van Snick J. Expression cloning of the murine and human interleukin 9 receptor cDNAs. Proc Natl Acad Sci U S A 1992; 89:5690-4.
  6. Demoulin JB, Van Roost E, Stevens M, Groner B, Renauld JC. Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9. J Biol Chem 1999;274:25855-61.
  7. Van Snick J, Houssiau F, Proost P, Van Damme J, Renauld JC. I-309/T cell activation gene-3 chemokine protects murine T cell lymphomas against dexamethasone-induced apoptosis. J Immunol. 1996; 157:2570-6.
  8. Knoops L, Hornakova T, Royer Y, Constantinescu SN, Renauld JC. JAK kinases overexpression promotes in vitro cell transformation. Oncogene 2008; 27:1511-9
  9. Dumoutier L, Van Roost E, Colau D, Renauld JC. Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocytestimulating factor. Proc Natl Acad Sci U S A 2000;97:10144-9.
  10. Dumoutier L, Lejeune D, Colau D, Renauld JC. Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J Immunol 2001;166:7090-5.
  11. Dumoutier L, Leemans C, Lejeune D, Kotenko SV, Renauld JC. Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. J Immunol 2001;167:3545-9.
  12. Renauld JC. Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators. Nature Rev Immunol 2003;3:667-676.
  13. Dumoutier L, Tounsi A, Michiels T, Sommereyns C, Kotenko SV, Renauld JC. Role of the Interleukin-28 Receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/IFN-lambda 1: Similarities with type I Interferon signalling. J Biol Chem 2004;279:32269-74.