Cytokines in immunity and inflammation group
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Jean-Christophe
RENAULD, Member
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The cytokine group studies the biology of Interleukin-9 (IL-9) and IL-22, two cytokines discovered at the Branch. IL-9 is a TH2 cytokine that plays a role in immune responses against intestinal parasites and asthma. IL-22, originally identified as a gene induced by IL-9 in T lymphocytes, upregulates the production of acute phase reagents in the liver. Its activity in inflammatory responses is modulated by a specific antagonist, the IL-22 binding protein (IL-22BP). The role of IL-9 and IL-22 in inflammation is currently being investigated using transgenic and gene-targeted mice for these cytokines and their receptors.
- Interleukin 9
Jean-Christophe Renauld, Jacques Van Snick, Laurent Knoops, Valérie Steenwinckel, Monique Stevens - IL-9
receptor and signal transduction
[Figure
1]
Jean-Christophe Renauld, Laurent Knoops, Tekla Hornakova, Monique Stevens - Anti-apoptotic
activity of I-309 receptor and signal
transduction
Jean-Christophe Renauld, Amel Tounsi, Jacques Van Snick - Role of JAK
overexpression in tumor cell
transformation
Jean-Christophe Renauld, Laurent Knoops, Tekla Hornakova, Monique Stevens - IL-TIF/IL-22 : a new cytokine
structurally related to IL-10
[Figure 2]
Laure Dumoutier, Magali de Heusch, Jean-Christophe Renauld - LICR2: a new cytokine receptor mediating
antiviral activities
Jean-Christophe Renauld, Laure Dumoutier
Selected publications
- Renauld JC, van der Lugt N, Vink A, van Roon M, Godfraind C, Warnier G, Merz H, Feller A, Berns A, Van Snick J. Thymic lymphomas in interleukin 9 transgenic mice. Oncogene 1994; 9:1327-32.
- Vink A, Warnier G, Brombacher F, Renauld JC. Interleukin 9-induced in vivo expansion of the B-1 lymphocyte population. J Exp Med 1999;189:1413-23.
- Richard M, Grencis RK, Humphreys NE, Renauld JC, Van Snick J. Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice. Proc Natl Acad Sci U S A 2000;97:767-72.
- Steenwinckel V, Louahed J, Orabona C, Huaux F, Warnier G, McKenzie A, Lison D, Levitt R, Renauld JC. IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells. J Immunol. 2007; 178:3244-51.
- Renauld JC, Druez C, Kermouni A, Houssiau F, Uyttenhove C, Van Roost E, Van Snick J. Expression cloning of the murine and human interleukin 9 receptor cDNAs. Proc Natl Acad Sci U S A 1992; 89:5690-4.
- Demoulin JB, Van Roost E, Stevens M, Groner B, Renauld JC. Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9. J Biol Chem 1999;274:25855-61.
- Van Snick J, Houssiau F, Proost P, Van Damme J, Renauld JC. I-309/T cell activation gene-3 chemokine protects murine T cell lymphomas against dexamethasone-induced apoptosis. J Immunol. 1996; 157:2570-6.
- Knoops L, Hornakova T, Royer Y, Constantinescu SN, Renauld JC. JAK kinases overexpression promotes in vitro cell transformation. Oncogene 2008; 27:1511-9
- Dumoutier L, Van Roost E, Colau D, Renauld JC. Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocytestimulating factor. Proc Natl Acad Sci U S A 2000;97:10144-9.
- Dumoutier L, Lejeune D, Colau D, Renauld JC. Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J Immunol 2001;166:7090-5.
- Dumoutier L, Leemans C, Lejeune D, Kotenko SV, Renauld JC. Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. J Immunol 2001;167:3545-9.
- Renauld JC. Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators. Nature Rev Immunol 2003;3:667-676.
- Dumoutier L, Tounsi A, Michiels T, Sommereyns C, Kotenko SV, Renauld JC. Role of the Interleukin-28 Receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/IFN-lambda 1: Similarities with type I Interferon signalling. J Biol Chem 2004;279:32269-74.